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While many texts indicate that methylene blue has oxidizing agent properties, its effects as an oxidizing agent occur only at very high doses.[citation needed] At pharmacologic doses it has reducing agent properties. It can also be effective in treating fish infected with ich although a combination of malachite green and formaldehyde is far more effective against the parasitic protozoa Ichthyophthirius multifiliis. K.; Wardman, P (2003). Elsevier Health Sciences. The American Society of Health-System Pharmacists. (2009). "PLOS ONE". doi:10.1186/1475-2875-5-84. Preparation[edit].

(November 2005). Peroxide generator[edit]. Dev. Solutions of this substance are blue when in an oxidizing environment, but will turn colorless if exposed to a reducing agent. PMID19180895. ^ Zacks Zacks SI (1973) The Motor Endplate, 2nd ed. It can also be used as an indicator to determine whether eukaryotic cells such as yeast are alive or not. Methylene blue has been described as "the first fully synthetic drug used in medicine." Its use in the treatment of malaria was pioneered by Paul Guttmann and Paul Ehrlich in 1891.

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